A Dedicated Spanish Language Line Increases Enrollment of Hispanics Into Prehospital Clinical Research

作者：Sanossian Nerses^*; Rosenberg Lauren; Liebeskind David S; Starkman Sidney; Eckstein Marc; Stratton Samuel; Pratt Franklin D; Hamilton Scott; Kim Tenser May; Sharma Latisha K; Restrepo Lucas; Valdes Suieras Miguel; Conwit Robin; Saver Jeffrey L

来源：Stroke, 2017, 48(5): 1389-1391.

DOI：10.1161/STROKEAHA.117.014745

• ambulances
• cell phones
• clinical trial
• magnesium
• stroke

Background and Purpose-Novel methods are needed to reduce the disparity of Hispanic enrollment in stroke clinical trials. Prehospital enrollment using a dedicated Spanish language line may help overcome this bias.
Methods-Subjects or legally authorized representatives provided information on race and ethnicity for all cases enrolled in the FAST-MAG clinical trial (Field Administration of Stroke Therapy-Magnesium), a prehospital phase 3 randomized study of intravenous magnesium for neuroprotection. One of 2 in-ambulance cell phones (in English or Spanish) was used to obtain informed content in the field. We describe the yield and characteristics of subjects enrolled via Spanish line.
Results-There were 1700 subjects enrolled from 2005 to 2012, of which 402 (24%) identified as Hispanic ethnicity. Study racial makeup was 1325 (78%) white, 219 (13%) black, and 139 (8%) Asian. The dedicated Spanish line was used for 195 (12%) enrollments. Spanish-line enrollments were younger (65 versus 70 years old; P<0.001), more likely to identify as Hispanic (98% versus 14%; P<0.001), and more likely to present with intracerebral hemorrhage (36% versus 21%; P<0.001).
Conclusions-The use of a dedicated Spanish language enrollment line allowed for greater enrollment of Hispanics, a population with significantly different baseline characteristics.

• 出版日期2017-5
• 单位NIH