New dimeric and trimeric coumarin glucosides from Daphne retusa Hemsl

作者：Mansoor Farrukh; Anis Itrat^*; Ali Sajjad; Choudhary Muhammad Iqbal; Shah Muhammad Raza

来源：Fitoterapia, 2013, 88: 19-24.

DOI：10.1016/j.fitote.2013.03.029

• Thymelaeaceae
• Daphne retusa
• Coumarin
• Glucoside
• Radical scavenging activity

New dimeric and a trimeric coumarin glucosides namely Daphneretusin A (1) Daphnerefusin B (2) along with three known oligomers (3-5) were obtained as a result of bioassay guided fractionation of Daphne retusa Hemsl. Fractions (n-hexane, CHCl3, AcOEt, CH3OH and water) exhibited potent radical scavenging activity in relevant non-physiological bioassays. The structures of isolated compounds were elucidated by UV, IR, EIMS, FAB-MS, 1D, and 2D NMR spectroscopic analysis.

• 出版日期2013-7