NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms

作者：Yu, Li; Li, Ling; Medeiros, L. Jeffrey; Young, Ken H.^*

来源：Blood Reviews, 2017, 31(2): 77-92.

DOI：10.1016/j.blre.2016.10.001

• NF-kappa B pathway
• B-cell lymphoma
• Apoptosis
• MiRNA
• Tumor microenvironment
• EBV

The NF-kappa B pathway, a critical regulator of apoptosis, plays a key role in many normal cellular functions. Genetic alterations and other mechanisms leading to constitutive activation of the NF-kappa B pathway contribute to cancer development, progression and therapy resistance by activation of downstream anti-apoptotic pathways, unfavorable microenvironment interactions, and gene dysregulation. Not surprisingly, given its importance to normal and cancer cell function, the NF-kappa B pathway has emerged as a target for therapy. In the review, we present the physiologic role of the NF-kappa B pathway and recent advances in better understanding of the pathologic roles of the NF-kappa B pathway in major types of lymphoid neoplasms. We also provide an update of clinical trials that use NF-kappa B pathway inhibitors. These trials are exploring the clinical efficiency of combining NF-kappa B pathway inhibitors with various agents that target diverse mechanisms of action with the goal being to optimize novel therapeutic opportunities for targeting oncogenic pathways to eradicate cancer cells.

• 出版日期2017-3
• 单位南昌大学; 郑州大学