Acute Morphine Exposure Increases the Brain Distribution of [F-18]DPA-714, a PET Biomarker of Glial Activation in Nonhuman Primates

作者：Auvity Sylvain; Saba Wadad; Goutal Sebastien; Leroy Claire; Buvat Irene; Cayla Jerome; Caille Fabien; Bottlaender Michel; Cisternino Salvatore; Tournier Nicolas^*

来源：International Journal of Neuropsychopharmacology, 2017, 20(1): pyw077.

DOI：10.1093/ijnp/pyw077

• neuroinflammation
• TSPO
• translocator protein 18 kDa
• neuroimmunopharmacology
• opioid.

Background: The neuroinflammatory response to morphine exposure modulates its antinociceptive effects, tolerance, and dependence. Positron emission tomography radioligands for translocator protein-18kDa such as [F-18] DPA-714 are noninvasive biomarkers of glial activation, a hallmark of neuroinflammation.
Methods: [F-18] DPA-714 positron emission tomography imaging was performed in 5 baboons at baseline and 2 hours after i.m. morphine injection (1 mg/kg). Brain kinetics and metabolite-corrected input function were measured to estimate [F-18] DPA-714 brain distribution.
Results: Morphine significantly increased [F-18] DPA-714 brain distribution by a 1.3 factor (P<.05; paired t test). The effect was not restricted to opioid receptor-rich regions. Differences in baseline [F-18] DPA-714 binding were observed among baboons. The response to morphine predominated in animals with the highest baseline uptake.
Conclusions: [F-18] DPA-714 positron emission tomography imaging may be useful to noninvasively investigate the brain immune component of morphine pharmacology. Correlation between baseline brain distribution and subsequent response to morphine exposure suggest a role for priming parameters in controlling the neuroinflammatory properties of opioids.

• 出版日期2017-1
• 单位中国地震局