A Unique Pathway for the 3-Aminobutyrate Starter Unit from L-Glutamate through beta-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

作者：Takaishi Makoto; Kudo Fumitaka; Eguchi Tadashi^*

来源：Organic Letters, 2012, 14(17): 4591-4593.

DOI：10.1021/ol302052c

Incednine is a 24-membered macrolactam antibiotic produced by Streptomyces sp. ML694-90F3. A previous study demonstrated that its unique nitrogen-containing starter unit was derived from L-glutamate. To elucidate the missing link between L-glutamate and the starter unit, deuterium labeled amino acid feeding experiments were conducted. These experiments revealed that 3[3-H-2]aminobutyrate end beta-[2,2,4,4-H-2(4)]glutamate were incorporated into the starter moiety. The results indicate that a novel decarboxylation of beta-glutamate to give 3-aminobutyrate is involved in incednine biosynthesis.

• 出版日期2012-9-7