The effect of enteral supplementation of a prebiotic mixture of non-human milk galacto-, fructo- and acidic oligosaccharides on intestinal permeability in preterm infants

作者：Westerbeek Elisabeth A M; van den Berg Anemone; Lafeber Harrie N; Fetter Willem P F; van Elburg Ruurd M^*

来源：British Journal of Nutrition, 2011, 105(2): 268-274.

DOI：10.1017/S0007114510003405

• Preterm infants
• Intestinal permeability
• Prebiotics

Preterm infants have an impaired gut barrier function. We aimed to determine the effects of enteral supplementation of a prebiotic mixture consisting of neutral oligosaccharides (short-chain galacto-oligosaccharides ((SC)GOS)/long-chain fructo-oligosaccharides (LCFOS)) and acidic oligosaccharides (AOS) on intestinal permeability of preterm infants as measured by the sugar absorption test in the first week of life. Furthermore, we determined host-and treatment-related factors associated with intestinal permeability. In a randomised controlled trial, preterm infants with a gestational age <32 weeks and/or birth weight (BW) <1500 g received enteral supplementation of (SC)GOS/LCFOS/AOS or placebo (maltodextrin) between days 3 and 30 of life. Intestinal permeability, reflected by the urinary lactulose/mannitol (L/M) ratio after oral ingestion of lactulose and mannitol, was assessed at three time points: before the start of the study (t=0), at day 4 (t=1) and at day 7 (t=2) of life. Data were analysed by generalised estimating equations. In total, 113 infants were included. Baseline patient and nutritional characteristics were not different between the SCGOS/LCFOS/AOS (n 55) and the placebo groups (n 58). (SC)GOS/LCFOS/AOS had no effect on the L/M ratio between t = 0 and t = 2. In both the groups, the L/M ratio decreased from t = 0 to t = 2 (P<0.001). Low BW increased the L/M ratio (P=0.002). Exclusive breast milk feeding and mixed breast milk/formula feeding during the first week of life decreased the L/M ratio (P<0.001 and P<0.05, respectively). In conclusion, enteral supplementation of a prebiotic mixture does not enhance the postnatal decrease in intestinal permeability in preterm infants in the first week of life.

• 出版日期2011-1