Neurolytic effects of ampicillin on the rat infraorbital nerve

作者：Saulacic Nikola^*; Lombardi Tommaso; Stojcev Stajcic Ljiljana; Iizuka Tateyuki; Stajcic Zoran

来源：Journal of Oral Pathology & Medicine, 2012, 41(3): 268-271.

DOI：10.1111/j.1600-0714.2011.01098.x

• ampicillin
• infraorbital nerve
• rat

PURPOSE: The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin.
MATERIALS AND METHODS: The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy.
RESULTS: Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth postoperative week.
CONCLUSION: Ampicillin can cause peripheral nerve damage when injected perineurally. J Oral Pathol Med (2012) 41: 268-271

• 出版日期2012-3