Toll like receptors in diseases of the lung

作者：Kovach Melissa A; Standiford Theodore J^*

来源：International Immunopharmacology, 2011, 11(10): 1399-1406.

DOI：10.1016/j.intimp.2011.05.013

• Pathogen recognition receptors
• Immunity
• PAMPs
• DAMPs
• Lung

The lung is in continuous contact with a diverse array of infectious agents, foreign antigens, and host-derived danger signals. To sample this expansive internal and external milieu, both resident myeloid and stromal/structure cells of the lung express a full complement of toll like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs). TLRs play a vital role in immune host defense against bacterial, mycobacterial, fungal, and viral pathogens of the lung. Additionally, TLRs contribute to disease pathogenesis in non-infectious pulmonary disorders, including airway disease, acute lung injury, and interstitial lung disease. In this review, TLR biology in the context of experimental infectious and non-infectious lung disease is discussed, and correlates to human lung disease, including therapeutic implications of these findings, are defined.

• 出版日期2011-10