Amino-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Levels 3 Months After Myocardial Infarction Are More Strongly Associated With Magnetic Resonance-Determined Ejection Fraction Than NTproBNP Levels in the Acute Phase

作者：Mistry Nisha; Abdelnoor Michael; Seljeflot Ingebjorg; Hoffmann Pavel; Bohmer Ellen; Bjornerheim Reidar; Kjeldsen Sverre E; Halvorsen Sigrun^*

来源：Journal of Cardiac Failure, 2011, 17(6): 479-486.

DOI：10.1016/j.cardfail.2011.02.006

• Natriuretic peptides
• left ventricular function
• magnetic resonance imaging

Background: The relationship between levels of amino-terminal pro B-type natriuretic peptide (NT-proBNP) and left ventricular function determined by magnetic resonance imaging (MR') in ST-segment-elevation myocardial infarction (STEMI) is largely unknown.
Methods and Results: This was a substudy of the Norwegian Study on District Treatment of STEMI, in which patients received thrombolysis followed by early or late invasive strategy. NT-proBNP was measured at 3 days and 3 months after the myocardial infarction, and magnetic resonance imaging was performed after 3 months (n = 160). Log NT-proBNP levels at both time points were significantly associated with ejection fraction (EF) (r(2) values 0.25 and 0.42, respectively) as well as infarct size (r(2) values 0.38 and 0.47, respectively; P < .0001 for all, adjusted for confounders). Furthermore, receiver operating characteristic (ROC) curves used to analyze the ability of NT-proBNP to discriminate long-term low EF (<= 40%) and large infarct size (>= 15.7%), were significant at both time points (P < .001 for all). Pairwise comparison of the ROC curves showed a significantly better performance of NT-proBNP at 3 months compared with 3 days for discrimination of low EF (P = .023).
Conclusion: Repeated measurements of NT-proBNP in STEMI patients showed that NT-proBNP levels at 3 months were more strongly associated with long-term EF and infarct size than NT-pro BNP levels after 3 days. Our data suggest that measurement of NT-proBNP 3 months after myocardial infarction is a better indicator of left ventricular function compared with NT-proBNP in the acute phase. (J Cardiac Fail 2011;17:479-486)

• 出版日期2011-6