AUTOREGULATION OF THE HUMAN WT1 GENE PROMOTER

作者：MALIK KTA^*; POIRIER V; IVINS SM; BROWN KW

来源：FEBS Letters, 1994, 349(1): 75-78.

DOI：10.1016/0014-5793(94)00642-3

• WILMS TUMOR GENE
• PROMOTER REGULATION

The human Wilms tumour suppressor gene, WT1, encodes a zinc-finger protein which can function as a transcriptional activator or suppressor. This study reports the analysis of the human WT1 gene promoter, and demonstrates that high levels of WT1 expression lead to autosuppression of the WT1 promoter. Deletion analyses of the promoter region implicate sequences 5' and 3' of the transcriptional start site as being crucial in WT1 autosuppression. Loss or alteration of this function of WT1 may be important in tumourigenesis.

• 出版日期1994-7-25