Aspirin Responsiveness in Ischemic Stroke Patients in Relation to Diabetes Mellitus, Lipid and Hemostatic Profile

作者：Sobol Anna B^*; Selmaj Krzysztof; Mochecka Alina; Kumor Anna; Loba Jerzy

来源：Advances in Clinical and Experimental Medicine, 2010, 19(5): 593-599.

• aspirin responsiveness
• blood coagulation
• diabetes mellitus
• ischemic stroke
• lipoprotein(a)

Background. The problem of aspirin responsiveness in ischemic stroke patients is still not clear.
Objectives. The aim of the study was to assess aspirin responsiveness in stroke patients in relation to diabetes mellitus, hemostatic and lipid profile.
Material and Methods. 64 patients (22 with diabetes, 41 men, mean age 57.9 +/- 10.4 years) with ischemic stroke or transient ischemic attack treated with the routine dose of 150 mg acetylsalicylic acid (ASA) daily were included into this study. Aspirin responsiveness was assessed based on platelet reactivity using platelet function analyzer (PFA-100 (TM)) with collagen/epinephrine cartridges and whole blood platelet aggregometry with 0.5 mM arachidonic acid on the first day of acute stroke and after 10 days of a 150 mg ASA intake. Lipid and hemostatic profiles were determined.
Results. The authors observed ASA unresponsiveness in 6/22 (27.3%) of diabetic and in 17/42 (40.5%) of non-diabetic patients (no significant differences). Lipoprotein(a) was higher in ASA-unresponsive compared with ASA-responsive patients - before ASA treatment 43 (4-102) mg/dl vs. 27 (4-130) mg/dl, p = 0.03 as well after 10 days of ASA treatment 37 (4-94) mg/dl vs 27 (1-90) mg/dl, p = 0.01.
Conclusions. The authors suggest that the prevalence of diabetes mellitus and hemostatic profile in ischemic stroke patients should not be associated with ASA unresponsiveness. The enhanced lipoprotein(a) might indicate ASA-un-responsive stroke patients (Adv Clin Exp Med 2010, 19, 5, 593-599).

• 出版日期2010