Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation

作者：Jin Zhen; Jung Yohan; Yi Chin ok; Lee Jong Youl; Jeong Eun Ae; Lee Jung Eun; Park Ki Jong; Kwon Oh Young; Lim Byeong Hoon; Choi Nack Cheon; Roh Gu Seob^*

来源：Korean Journal of Physiology and Pharmacology, 2018, 22(3): 301-309.

DOI：10.4196/kjpp.2018.22.3.301

• Atorvastatin
• Hippocampal cell death
• Kainic acid
• Lipocalin-2
• Seizures

Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cycloox ygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.

• 出版日期2018-5