Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

作者：Majdinasab Nastaran; Motl Robert W; Mokhtarzade Motahare^*; Zimmer Philipp; Ranjbar Rouholah; Keytsman Charly; Cullen Tom; Negaresh Raoof; Baker Julien S

来源：Complementary Therapies in Clinical Practice, 2018, 31: 295-301.

DOI：10.1016/j.ctcp.2018.03.004

• Multiple sclerosis
• Cytokines
• Inflammation
• Adipokines
• Aerobic interval exercise

Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).
Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.
Results: Levels of IL-10 and TNF-alpha in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-alpha levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.
Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

• 出版日期2018-5