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摘要
Objectives: We performed this meta-analysis aiming to discuss the association of ataxia telangiectasia mutated (ATM) rs1801516 polymorphism with the risk of thyroid cancer (TC). Methods: Eligible publications were retrieved through database search. The strength of association between ATM rs1801516 polymorphism and the risk of TC was evaluated by pooled odds ratio (OR) with 95% confidence interval (95% CI). In addition, subgroup analyses were also carried out based on ethnicity and control source. Sensitivity analysis was completed to test statistical stability of the final results, and publication bias among included studies was inspected with both Begg's funnel plot and Egger's test. Data syntheses in this meta-analysis were conducted through Stata 12.0 software. Results: A total of 5 published articles including 8 case-control studies were enrolled into our meta-analysis, with 3,175 TC cases and 4,467 controls. The results showed that there was a significant association between decreased TC risk and ATM rs1801516 polymorphism in model AA+GA vs. GG (OR=0.88, 95% CI=0.79-0.98). Besides, a similar trend was also detected for the polymorphism in Caucasian group under the same genetic comparison after subgroup analysis by ethnicity. Conclusion: ATM rs1801516 polymorphism may reduce the susceptibility to TC, especially in Caucasians.
- 出版日期2017
- 单位湖北理工学院; 武汉大学
