A Diet Rich in Monounsaturated Fatty Acids Improves the Lipid Profile of Mice Previously on a Diet Rich in Saturated Fatty Acids

作者：Arapostathi Christina; Tzanetakou Irene P^*; Kokkinos Alexander D; Tentolouris Nicholas K; Vlachos Ioannis S; Donta Ismini A; Perrea Kalliopi N; Perrea Despina N; Katsilambros Nicholaos L

来源：Angiology, 2011, 62(8): 636-640.

DOI：10.1177/0003319711403734

• monounsaturated fatty acids
• saturated fatty acids
• diet
• lipid profile
• mice
• hypercholesterolemia

This study investigated whether switching from a diet rich in saturated fatty acids (SAFAs) to a diet rich in monounsaturated fatty acids (MUFAs) or to one with equal amounts of MUFAs-SAFAs favorably affects the lipid profile of hypercholesterolemic mice. C57BL/6 mice (n = 82) were allocated into 4 groups. The first group (control, n 10) was fed standard chow. The 3 remaining groups (n 24 mice/group) were fed a SAFA-rich diet for 8 weeks and were then allocated for 16 weeks to either a MUFA-rich diet, an equal in MUFAs-SAFAs-rich diet, or continued the previous SAFA-rich diet. After 8 weeks, mice consuming SAFA-rich diet had increased weight, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) levels (P <.05 vs baseline). At week 24, MUFA-rich and MUFA-SAFA rich diets decreased TC and low-density lipoprotein cholesterol (LDL-C) levels (P <.05) compared with week 8. In conclusion, switching to MUFA-rich diets or substituting half of the SAFAs with MUFAs can reverse diet-induced-hypercholesterolemia.

• 出版日期2011-11