Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children

作者：Fu, Yanrong; Hu, Youfang; Qin, Zhenying; Zhao, Yan; Yang, Zi; Li, Yinfang; Liang, Guanyu; Lv, Heyun; Hong, Hong; Song, Yuan; Wei, Yarong; Yue, Hongni; Zheng, Wen; Liu, Guoqin; Ni, Yufei; Zhu, Mei; Wu, Aiping; Yan, Juhua; Ji, Chenbo; Guo, Xirong; Wen, Juan^*; Qin, Rui^*

来源：Oncotarget, 2016, 7(49): 80811-80819.

DOI：10.18632/oncotarget.13097

• serum 25-hydoxyvitamin D
• bone mineral density
• 0-7 year old children

Objective: To describe the status of serum 25-hydoxyvitamin D [25(OH) D] concentrations and identify the relationship between 25(OH) D and bone mineral density (BMD). In an effort to explore the appropriate definition of vitamin D (VD) deficiency in 0-7 year old children.
Results: The median serum 25(OH) D concentrations was 62.9 nmol/L and 28.9% of the children had a low 25(OH) D (< 50 nmol/L). And a linear relation between 25(OH) D concentrations and BMD was surveyed (r = 0.144, P < 0.001). After adjusting for the confounders, serum 25(OH) D was positively associated with BMD (beta = 172.0, 95% CI = 142.8-201.2, P < 0.001), and low 25(OH) D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95% CI = 1.145-1.769, P = 0.001). Additionally, there was a nonlinear relation between 25(OH) D and low BMD, and a critical value for 25(OH) D of 75 nmol/L appeared for low BMD. The prevalence of low BMD was 14.1% in children with 25(OH) D >= 75 nmol/L, much lower than that of the concentrations between 50-75 nmol/L and < 50 nmol/L.
Materials and Methods: A total of 4,846 children 0-7 years old were recruited in Jiangsu Province, China. BMD and serum 25(OH) D concentrations were determined by quantitative ultrasound and enzyme-linked immunosorbent assay, respectively. Linear regression and logistic regression analyses were used to assess the association of 25(OH) D concentrations with BMD.
Conclusions: Serum 25(OH) D concentrations was related with BMD and 25(OH) D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0-7 year old children.

• 出版日期2016-12-6
• 单位南京医科大学