Association Between HIF-1 Alpha Gene Polymorphisms and Response in Patients Undergoing Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer

作者：Chen, Qing^*; Tian, Wei-Jie; Huang, Miao-Ling; Liu, Chang-Hao; Yao, Ting-Ting; Guan, Mei-Mei

来源：MEDICAL SCIENCE MONITOR, 2016, 22: 3140-3146.

DOI：10.12659/MSM.897486

• Biomarkers, Pharmacological
• Hypoxia-Inducible Factor 1
• Neoadjuvant Therapy
• Uterine Cervical Neoplasms

Background: The aim of the study was to assess whether HIF-1 alpha polymorphisms have an effect on the response to chemotherapy of locally advanced cervical cancer (LACC) patients treated with platinum-based neoadjuvant chemotherapy (NACT) and radical surgery. @@@ Material/Methods: We conducted a retrospective study in 162 LACC patients. Hypoxia-inducible factor 1 alpha C1772T and G1790A genetic polymorphisms were ascertained using direct sequencing methods. @@@ Results: The C1772T polymorphism was significantly related to response to chemotherapy (P=0.002), and there was an increased chance of treatment response in patients with the C/C genotype (OR=4.7; 95% CI: 1.67-13.49; P=0.004). The C1772T polymorphism was also associated with poor tumor grade (adjusted OR, 2.98; 95% CI: 1.08-8.13; P=0.037). However, The G1790A polymorphism was not associated with response (P>0.05). @@@ Conclusions: The C1772T polymorphism was significantly related to response to chemotherapy and poor tumor grade. Our results may help to better manage individual patients and to improve clinical decision making regarding use of NACT.

• 出版日期2016-9-5
• 单位贵州省人民医院; 中山大学