Documenting family history in children with hypercholesterolaemia: A lost opportunity

作者：Sorubarajan, Tharmarajah^*; Lewis, Barry D.; Burnett, John R.; Martin, Andrew C.

来源：Journal of Paediatrics and Child Health, 2017, 53(5): 470-473.

DOI：10.1111/jpc.13457

• cardiovascular disease
• children
• familial hypercholesterolaemia
• family history

Aim: To determine whether information about a family history of hypercholesterolaemia or early cardiovascular disease was documented by paediatricians in children and adolescents with elevated low-density lipoprotein (LDL)-cholesterol levels. @@@ Methods: Retrospective chart review of all children with a LDL-cholesterol level >= 95th percentile (3.4 mmol/L) and >= 99th percentile (3.8 mmol/L) at a tertiary paediatric hospital in 2014. @@@ Results: Of 86 children with a LDL-cholesterol level >= 3.4 mmol/L, only 18 (20.9%) had documentation of a family history of hypercholesterolaemia or early cardiovascular disease. In those 18, 13 (72.2%) had a family history of hypercholesterolaemia and 11 (61.1%) a family history of early cardiovascular disease. Increasing the LDL-cholesterol cut-off level to >= 3.8 mmol/L (n = 46) did not improve documentation of a family history (9/46, 19.6%). @@@ Conclusions: In patients with elevated LDL-cholesterol levels, paediatricians rarely document a positive or negative family history of hypercholesterolaemia or early cardiovascular disease. This represents a lost opportunity to diagnose children and adolescents with familial hypercholesterolaemia.

• 出版日期2017-5