Altered Neurotransmitter Levels with Post-Traumatic Stress Disorder

作者：Zhang Gui qing; Yang Jian xia; Zhang Yue qi; Liang Xia; Hu Min; Fan Jian^*

来源：Turkish Neurosurgery, 2014, 24(6): 844-848.

DOI：10.5137/1019-5145.JTN.8723-13.1

• Post-traumatic stress disorders (PTSD)
• Neurotransmitter
• Correlation

AIM: The aim of this study was to observe the changes in the monoamine neurotransmitter levels of patients with post-traumatic stress disorder (PTSD) and explore whether the neurotransmitter level is correlated with the severity of PTSD.
MATERIAL and METHODS: A total of 15 PT-SD patients without any physical injuries were enrolled into the study. Another 15 cases of pre-restoration patients were recruited as controls who experienced traumatic events but did not experience PTSD or had a Posttraumatic stress disorder Check List-Civilian version (PCL-C) score lower than 12 points. The levels of plasma monoamine neurotransmitters, including norepinephrine, 5-hydroxytryptamine, and dopamine, were tested using enzyme-linked immunosorbent assays.
RESULTS: No significant differences were found between the monoamine neurotransmitter levels of the PTSD and the control groups (p > 0.05). A correlation study confirmed that the monoamine neurotransmitter levels and the PCL-C scores of the PTSD group were not significantly correlated (p > 0.05).
CONCLUSION: No neurotransmitter changes are seen in PTSD caused by simple mental trauma, and the PCL-C scores do not associate with PTSD.

• 出版日期2014-11
• 单位石河子大学