An antimicrobial zinc based molecule for cross linking poly-acrylic acid

作者：James Charlotte; Pugh Thomas; Johnson Andrew L; Jenkins A Tobias A^*

来源：European Polymer Journal, 2011, 47(6): 1338-1345.

DOI：10.1016/j.eurpolymj.2011.02.010

• Acrylic-acid
• Superabsorbent
• Antimicrobial
• Crosslinker
• Zinc

A system for incorporating antimicrobial zinc into polymeric materials, in particular hydrogel type polymers has been developed. Zn(Bipy-(MMOES)(2)) a zinc carboxylate monomer was designed with the purpose of mimicking commercial cross linking agents such as ethylene glycol diacrylate, as well as containing antimicrobial zinc ions (Zn(2+)), with the intention that it can be used to cross link into any polymeric material, the example here being polyacrylic acid. Two systems were studied: a homopolymer of the Zn(Bipy-(MMOES)(2)) and copolymers of Zn(Bipy-(MMOES)(2)) with acrylic acid (AA). The AA - Zn(Bipy-(MMOES)(2)) produced water swellable polymers which retained antimicrobial activity. The ability of the polymers to release the zinc ions was shown to be pH responsive and the leachate analysed to give a proposed mechanism of action. The Zn(Bipy-(MMOES)(2)) monomer and polymers have shown antibacterial activity against both gram positive Methicillin susceptible staphylococcus aureus (MSSA 476) and gram negative Pseudomonas aeruginosa (PA01).

• 出版日期2011-6