Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons

作者：Fusaoka Nishioka Eri; Shimono Chisei; Taniguchi Yukimasa; Togawa Aki; Yamada Akio; Inoue Eiji; Onodera Hiroshi; Sekiguchi Kiyotoshi; Imai Toshio^*

来源：Neuroscience Research, 2011, 71(4): 421-426.

DOI：10.1016/j.neures.2011.08.012

• Extracellular matrix
• Axon outgrowth
• Dendrite outgrowth
• Dendrite sprouting
• Laminin E8 fragment
• Integrin

Laminins play an important role in neuronal development. However, the effects of each laminin isoform on neurite morphology remain unclear. Here, we examined the effects of particular laminin (LN) isoforms on hippocampal neuron morphology. We found that LN-511 remarkably promoted elongation of both axons and dendrites, but reduced the number of dendrites. LN-511 E8 fragment, which includes the integrin-binding region, promoted axon and dendrite outgrowth and increased the dendrite number, although its effect on axon and dendrite elongation was smaller than that of full-length LN-511. These results suggest that LN-511 regulates axon and dendrite development by integrin-dependent and -independent mechanisms.

• 出版日期2011-12