Dopamine D-1 receptor binding in the anterior cingulate cortex of patients with obsessive-compulsive disorder

作者：Olver James S^*; O'Keefe Graeme; Jones Gareth R; Burrows Graham D; Tochon Danguy Henri J; Ackermann Uwe; Scott Andrew M; Norman Trevor R

来源：Psychiatry Research: Neuroimaging , 2010, 183(1): 85-88.

DOI：10.1016/j.pscychresns.2010.04.004

• Dopamine
• Obsessive-compulsive disorder
• Positron emission tomography
• Anterior cingulate cortex

Functional neuroimaging studies in patients with obsessive-compulsive disorder (OCD) suggest there is a hyperactivation of the anterior cingulate cortex (ACC) during provocation of symptoms and conflict-inhibition tasks. Since dopamine, acting through D-1 receptors is suggested to modulate ACC activity, we hypothesised that there would be an altered D-1 binding potential (BP) in the ACC of OCD patients. Using [C-11]-SCH23390 and positron emission tomography, we report significantly reduced D-1 BP in seven drug-free OCD patients compared with matched healthy controls. These findings suggest mesocortical dopamine inputs via D-1 receptors may play a role in the aetiology of OCD.

• 出版日期2010-7-30