Determination of Idarubicin Using CdTe Quantum Dots as Fluorescence Probes

作者：Wei, Xiaofang^*; Huang, Xiande; Fang, Yan; Zhang, Qike^*

来源：Journal of Nanoscience and Nanotechnology, 2016, 16(7): 6992-6997.

DOI：10.1166/jnn.2016.13012

• CdTe Quantum Dots
• Idarubicin
• Fluorescence Probe

A simple and fast method for the determination of Idarubicin (IDA) was developed based on the fluorescence quenching effect of IDA for 3-mercaptopropionic acid-capped CdTe quantum dots. Under optimum conditions, the calibration plot of F-0/F versus the concentration of IDA was linear in the range of 1-200 mu M with correlation coefficient of 0.9969. The limit of detection was 0.2 mu M. The recoveries of IDA standard solution spiked with sample were in the range of 99.75-100.9% with the relative standard deviations less than 5.0%. The method was applied to the determination of IDA in its commercial powder-injection sample and the result agreed with the claimed values. The mechanism of the fluorescence quenching was discussed.

• 出版日期2016-7
• 单位甘肃省人民医院