A Meta-analysis of the Association between p53 Codon 72 Polymorphism and Susceptibility to Endometriosis

作者：Song Gwan Gyu; Lee Young Ho^*

来源：Immunological Investigations, 2014, 43(6): 595-605.

DOI：10.3109/08820139.2013.833623

• Endometriosis
• meta-analysis
• p53
• polymorphism

Objective: The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis.
Methods: A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast.
Results: Nine studies involving 1,803 patients and 2,006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921-1.282, p = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065-1.854, p = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123-3.730, p = 0.019).
Conclusions: This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans.

• 出版日期2014