Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats

作者：Choi Eun Young^*; Hwang Hye Jeong; Kim In Hye; Nam Taek Jeong

来源：Food and Chemical Toxicology, 2009, 47(1): 134-139.

DOI：10.1016/j.fct.2008.10.026

• Seaweed
• Polysaccharide
• Hizikia fusiformis
• Protectant
• JNK

Hizikia fusiformis is an edible brown alga that is widely consumed in Korea, Japan, and China and possesses a number of potentially beneficial compounds, including antioxidants and anticoagulants. No reports have investigated potential H. fusiformis protectants against ethanol-induced peptic injury. We extracted a polysaccharide from H. fusiformis (Hf-PS-1) that exhibited protective effects against ethanol-induced peptic injury and related mechanisms in rats. Experimental animals were divided into three groups: control, ethanol-only, and ethanol Hf-PS-1. The ethanol-only group exhibited decreased levels of total glutathione (GSH) and increased levels of jun N-terminal kinase (JNK) phosphorylation relative to the control group, whereas levels were significantly increased and decreased, respectively, in the ethanol Hf-PS-1 group. The ethanol-only group also exhibited increased levels of extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation relative to the control group; these levels were not significantly different in the ethanol Hf-PS-1 group. Hf-PS-1 appeared to reduce ethanol-induced gastric injury. Therefore, we suggest that Hf-PS-1 could protect against ethanol-induced peptic ulcers primarily through a mechanism associated with the inhibition of JNK activation.

• 出版日期2009-1