Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

作者：Khan Imran A; Jahan Parveen; Hasan Qurratulain; Rao Pragna^*

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2014, 15(4): 566-571.

DOI：10.1177/1470320313502106

• Gestational diabetes mellitus
• angiotensin-converting enzyme
• insertion
• deletion polymorphism
• type 2 diabetes mellitus
• polymerase chain reaction

Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations with different ethnic origins. The present study examined possible association between I/D polymorphism of the ACE gene and GDM in Asian Indian pregnant women.
Methods: A total of 200 pregnant women (100 GDM and 100 non-GDM) were recruited in this study and I/D polymorphism of a 287 bp Alu1 element inside intron 16 of the ACE gene was examined by polymerase chain reaction (PCR)-based gel electrophoresis.
Result: The distribution of the variants like II, ID, and DD genotypes of ACE gene showed differences between normal GDM versus non-GDM subjects, and the frequency of the ID+ DD Vs II genotype was significant (p=0.0002) in the GDM group.
Conclusion: ACE gene polymorphism was associated with GDM in Asian Indian pregnant women.

• 出版日期2014-12