In vivo cell death mediated by synthetic ion channels

作者:Smith Bryan A; Daschbach Megan M; Gammon Seth T; Xiao Shuzhang; Chapman Sarah E; Hudson Caroline; Suckow Mark; Piwnica Worms David; Gokel George W*; Leevy W Matthew
来源:Chemical Communications, 2011, 47(28): 7977-7979.
DOI:10.1039/c1cc12933c

摘要

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

  • 出版日期2011