An expedient microwave assisted regio-and stereoselective synthesis of spiroquinoxaline pyrrolizine derivatives and their AChE inhibitory activity

作者：Akondi Adinarayana Murthy; Mekala Sowmya; Kantam Mannepalli Lakshmi^*; Trivedi Rajiv^*; Chowhan L Raju; Das Amitava

来源：New Journal of Chemistry, 2017, 41(2): 873-878.

DOI：10.1039/c6nj02869a

In this study, we report an efficient four-component cascade protocol to afford spiro indeno[1,2-b] quinoxaline113'-pyrrolizines via the condensation of ninhydrin, phenylenediamine, proline, and nitrostyrene derivatives under microwave irradiation and classical conditions. The 1,3-dipolar cycloaddition reaction was found to proceed in a highly regio-and stereoselective manner. This methodology exemplifies the green chemistry protocol for the preparation of spiro-pyrrolizines. In addition, all the synthesized compounds were screened for AChE inhibitory activity and 6 out of 21 compounds depicted significant activity in the low micromolar IC50 range.

• 出版日期2017