Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus

作者：Goldeck David^*; Maetzler Walter; Berg Daniela; Oettinger Lilly; Pawelec Graham

来源：Journal of Neuroimmunology, 2016, 290: 60-65.

DOI：10.1016/j.jneuroim.2015.11.008

• Plasmacytoid dendritic cells
• Myeloid dendritic cells
• Ig-like transcript 2
• Cytomegalovirus

Parkinson's disease (PD) is characterised by low-level systemic inflammation, which may be at least partly due to pathophysiological activation of immunity. Here, the frequencies of different types of circulating dendritic cells (DCs) with and without a pro-inflammatory phenotype were determined in PD patients and controls. A high proportion of older people is infected with cytomegalovirus (CMV), which acts as a chronic antigenic stressor that could also contribute to increased inflammation. Following this idea, we found higher frequencies of myeloid DCs with a pro-inflammatory CD16+ILT2(high) phenotype in CMV-positive PD patients than controls, suggesting the potential involvement of CMV in exacerbating PD.

• 出版日期2016-1-15