A Meta-analysis of Central Corneal Thickness Changes With Overnight Orthokeratology

作者：Li, Fang; Jiang, Zhi-Xin; Hao, Peng; Li, Xuan^*

来源：Eye and Contact Lens: Science and Clinical Practice , 2016, 42(2): 141-146.

DOI：10.1097/ICL.0000000000000132

• Orthokeratology
• Meta-analysis
• Central corneal thickness

Objectives:
To assess the change of central corneal thickness (CCT) in the treatment of orthokeratology in patients with myopia.
Methods:
A systematic search of all relevant studies published through April 2014 was conducted, and 95% confidence intervals (CI) of CCT change were calculated. Random or fixed-effects models were used according to heterogeneity. Publication bias of the articles was evaluated using funnel plots and Begg test.
Results:
A total of 10 studies with 239 patients (339 eyes) from clinical studies were included. Central corneal thickness reduced significantly from 1 day to 1 week by 5.73 mu m (95% CI, 1.75-9.70 mu m; P=0.005), and a significant mean reduction of 5.89 mu m also occurred from 1 day to 1 month (95% CI, 3.50-8.29 mu m; P<0.001). No significant reduction was found between 1 week and 1 month (P=0.32).
Conclusions:
Our meta-analysis demonstrated that most reduction of CCT occurred during the first week and remained thinner for 1 month. Further randomized controlled trials with larger sample sizes, standardized outcome measurements, and different follow-up periods are warranted to find the precise change.

• 出版日期2016-3
• 单位南开大学; 天津市眼科医院