Antibiotic susceptibility patterns of bacteria isolated from keratitis and intraocular infections at Fundacion Oftalmologica de Santander (FOSCAL), Floridablanca, Colombia

作者：Galvis Virgilio; Tello Alejandro^*; Guerra Alfredo; Fernanda Acuna Maria; Villarreal Donaldo

来源：Biomedica, 2014, 34(0): 23-33.

DOI：10.7705/biomedica.v34i0.1636

• Bacteria
• drug resistance
• microbial
• anti-bacterial agents
• antibiotics
• eye infections
• keratitis
• endophthalmitis

Introduction: Bacterial resistance is critical for the selection of antibiotics in the treatment of infections, so it is vital to know its current status in our geographical area.
Objective: To determine in vitro antibiotic susceptibility of bacterial isolates obtained from keratitis and intraocular infections.
Materials and methods: A retrospective study of microbiological tests in Fundacion Oftalmologica de Santander (FOSCAL) was carried out between June, 2011, and January, 2012.
Results: A total of 92 samples were examined and 110 bacteria, 27 fungi and 12 free-living amoebae were identified. Polymicrobial infections constituted 50% of the total; 1.1%, 0%, 1.1%, 16.9%, 29.3% and 85% of Gram-positive bacteria were resistant to imipenem, moxifloxacin, gatifloxacin, levofloxacin, ciprofloxacin and tobramycin, respectively, while 0%, 8.3%, 0%, 0%, 18.2% and 27.3% of Gram-negative bacteria were resistant to imipenem, moxifloxacin, gatifloxacin, levofloxacin, ciprofloxacin and tobramycin, respectively. For methicillin-resistant coagulase-positive staphylococci, resistance percentages to imipenem, moxifloxacin, gatifloxacin, levofloxacin, ciprofloxacin and tobramycin were 0%, 0%, 0%, 7%, 17% and 100%, respectively. For methicillin-resistant coagulase-negative staphylococci, resistance percentages to imipenem, moxifloxacin, gatifloxacin, levofloxacin, ciprofloxacin and tobramycin were 3%, 0%, 0%, 24%, 44% and 100%, respectively. Overall bacterial resistance to imipenem, moxifloxacin, gatifloxacin, levofloxacin, ciprofloxacin and tobramycin, for both Gram-positive and Gram-negative, was 1%, 1%, 1%, 15.1%, 28% and 64.5%, respectively.
Conclusions: The levels of bacterial resistance to imipenem, moxifloxacin and gatifloxacin were lower than for levofloxacin, ciprofloxacin and tobramycin. The levels of resistance to tobramycin were very high, which calls into question its usefulness in this region of our country.

• 出版日期2014-4