Association of human platelet antigens polymorphisms with susceptibility to hepatitis C virus infection in Chinese population

作者：Zhou, S-H; Liang, X-H; Shao, L-N; Yu, W-J; Zhao, C.; Liu, M.^*

来源：International Journal of Immunogenetics, 2017, 44(6): 337-342.

DOI：10.1111/iji.12341

• allele
• genotype
• hepatitis C virus
• human platelet antigens
• single nucleotide polymorphism

Hepatitis C virus (HCV) is a major cause of chronic hepatitis. Previous studies have identified a number of single nucleotide polymorphisms that are associated with HCV infection. Human platelet antigens (HPAs) polymorphisms play an important role in several diseases. Here, we demonstrated the association of the HPA-2, HPA-3, HPA-5 and HP-15 polymorphisms with susceptibility to HCV infection in Chinese population. Overall, 118 patients with HCV and 167 controls were genotyped for HPAs. There were no significant differences in the allele and genotype frequency distribution for the HPA-3, HPA-5 and HPA-15 systems between the patients with chronic HCV infection and the healthy controls (p > .05). However, the genotype frequency of HPA-2aa was significantly lower, while HPA-2ab/bb was significantly higher in patients than that in the controls (p = .006). The allele frequency of HPA-2a in patients was significantly lower than that in the control group (p = .005). In contrast, HPA-2b in patients was significantly higher than that in the control group (p = .005). We conclude that HPA-2 polymorphism is associated with susceptibility to HCV infection, and individuals carrying the HPA-2b allele may have a higher risk of HCV infection compared with individuals carrying HPA-2a.

• 出版日期2017-12
• 单位大连医科大学