Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

作者:Bonnier Guillaume*; Roche Alexis; Romascano David; Simioni Samanta; Meskaldji Djalel Eddine; Rotzinger David; Lin Ying Chia; Menegaz Gloria; Schluep Myriam; Du Pasquier Renaud; Sumpf Tilman Johannes; Frahm Jens; Thiran Jean Philippe; Krueger Gunnar; Granziera Cristina
来源:Biomed Research International, 2015, 2015: 569123.
DOI:10.1155/2015/569123

摘要

Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability. Methods. 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2* relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances. Results. Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-R-2 = 0.6; P = 0.0005), executive Adj-R-2 = 0.5; P - 0.004), verbal memory (Adj-R-2 - 0.4; P - 0.02), and attention (Adj-R-2 - 0.5; P - 0.002). Conclusion. Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients' disability and cognitive dysfunction.

  • 出版日期2015