Advances in quantum dot-mediated siRNA delivery

作者：He Zhi Yao; Jin Zhao Hui; Zhan Mei; Qin Zhou; Li Zhi^*; Xu Ting^*

来源：Chinese Chemical Letters, 2017, 28(9): 1851-1856.

DOI：10.1016/j.cclet.2017.07.012

• Quantum dot
• Carbon quantum dot
• Small-interfering RNA
• Theranostic
• Gene delivery
• Gene therapy

Nano-sized quantum dots (QDs) exhibit uniquely optical properties that are tunable with different sizes and shapes. QDs can emit narrow symmetric bands under a wide excitation range, possess anti-photobleaching stability, and be bio-functionalized on the large surface area. Therefore, QDs are attractive vectors for imaging-guided therapy. Small-interfering RNA (siRNAs)-based therapeutics hold. great potential to target a large part of the currently undruggable genes, but overcoming the lipid bilayer to deliver siRNA into cells has remained a major challenge to solve for widespread development of siRNA therapeutics. In this mini-review, we focus on theranostic QD/siRNA assembles for enhancing delivery of siRNA and facilitating evaluation of therapeutic efficacy via imaging of QDs, with special attention to carbonaceous QDs for delivery of siRNA.

• 出版日期2017-9
• 单位四川大学