科研之友
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摘要
Recent clinical and preclinical research has suggested that cannabidiol (CBD) and Delta(9)-tetrahydrocannabinol (Delta(9)-THC) have interactive effects on measures of cognition; however, the nature of these interactions is not yet fully characterized. To address this, we investigated the effects of Delta(9)-THC and CBD independently and in combination with proposed therapeutic dose ratios of 1: 1 and 1: 3 Delta(9)-THC: CBD in adult rhesus monkeys (n = 6) performing a stop signal task (SST). Additionally, the development of tolerance to the effects of Delta(9)-THC on SST performance was evaluated by determining the effects of acutely administered Delta(9)-THC (0.1-3.2 mg/kg), during a 24-day chronic Delta(9)-THC treatment period with Delta(9)-THC alone or in combination with CBD. Results indicate that Delta(9)-THC (0.032-0.32 mg/kg) dose-dependently decreased go success but did not alter go reaction time (RT) or stop signal RT (SSRT); CBD (0.1-1.0 mg/kg) was without effect on all measures and, when coadministered in a 1: 1 dose ratio, did not exacerbate or attenuate the effects of Delta(9)-THC. When coadministered in a 1: 3 dose ratio, CBD (1.0 mg/kg) attenuated the disruptive effects of 0.32 mg/kg Delta(9)-THC but did not alter the effects of other Delta(9)-THC doses. Increases in ED50 values for the effects of Delta(9)-THC on SST performance were apparent during chronic Delta(9)-THC treatment, with little evidence for modification of changes in sensitivity by CBD. These results indicate that CBD, when combined with Delta(9)-THC in clinically available dose ratios, does not exacerbate and, under restricted conditions may even attenuate, Delta(9)-THC's behavioral effects.
- 出版日期2016-10
- 单位东北大学
