Determination of Aromatic Amines Released from Azo Dyes in Paper Packaging by Liquid Chromatography-Tandem Mass Spectrometry

作者：Yang Fei; Bian Zhaoyang; Li Zhonghao^*; Fan Ziyan; Wang Ying; Li Shanshan; Deng Humin; Tang Gangling

来源：Journal of AOAC International, 2016, 99(5): 1370-1376.

DOI：10.5740/jaoacint.16-0068

An LC-tandem MS (LC MS/MS) method for the determination of 21 kinds of carcinogenic aromatic amines released from azo dyes in food wrappers was used in this research. Sodium dithionite was added to a citric acid buffer medium to reduce and decompose possible azo dyes. The extract was analyzed after liquid liquid extraction (LLE) and dispersive SPE (d-SPE). The conditions for chromatographic separation, mass spectrum, LLE, and d-SPE were optimized. Under optimal conditions, the LOD was in the range of 0.13-0.35 mg/kg and LOQ in the range of 0.38-1.05 mg/kg, with the addition of standard recoveries of most aromatic amines being >= 80% and RSDs 510%. The recoveries for 2,4-diaminotoluene and 2,4-diaminoanisole were significantly lower, being <= 40%. The method was successfully used to analyze 30 practical samples, and the results showed that it is user-friendly, with high sensitivity, rapid control, and low matrix interference.

• 出版日期2016-10
• 单位国家烟草质量监督检验中心