Anthraquinones from the Roots of Knoxia valerianoides and their Anticancer Activity

作者：Yang, Xuan; Chou, Guixin; Ji, Lili; Han, Liting; Zhu, Enyuan^*

来源：Latin American Journal of Pharmacy, 2013, 32(1): 96-100.

• Anthraquinones
• Cytotoxic activity
• Cdc25B
• Hep3B
• Knoxia valerianoides

Anticancer compounds from the roots of Knoxia valerianoides Thorel et Pitard were investigated. Two anthraquinones, damnacanthol-omega-ethyl ether (1) and 3-hydroxy-2-hydroxymethyl anthraquinones (2) were isolated for the first time, along with seven other anthraquinones, lucidin (3), rubiadin (4), 3-hydroxymorindone (5), damnacanthol (6), nordamnacanthal (7), konxiadin (8) and 2-ethoxy-methylknoxiavaledin (9). Three of these anthraquinones (compounds 3-5) showed remarkable cytotoxicity against human hepatoma Hep3B cells, human gastric cancer AGS cells and human breast cancer MDA-MB-231 cells but had no significant effects human normal liver L-02 cells. And they also performed inhibitory activities on cell division cycle 25B (Cdc25B) phosphatase.

• 出版日期2013
• 单位上海中药标准化研究中心; 上海中医药大学