A randomized controlled trial of flunarizine as add-on therapy and effect on cognitive outcome in children with infantile spasms

作者：Bitton Jonathan Y; Sauerwein Hannelore C; Weiss Shelly K; Donner Elizabeth J; Whiting Sharon; Dooley Joseph M; Snead Carter; Farrell Kevin; Wirrell Elaine C; Mohamed Ismail S; Ronen Gabriel M; Salas Prato Milagros; Amre Devendra; Lassonde Maryse; Carmant Lionel^*

来源：Epilepsia, 2012, 53(9): 1570-1576.

DOI：10.1111/j.1528-1167.2012.03623.x

• West syndrome
• Neuroprotection
• Cognition
• Developmental outcome
• Calcium channel blocker
• Vigabatrin
• Synthetic adrenocorticotropic hormone
• Steroids
• Epileptic encephalopathy

Purpose: Cognitive impairment is observed commonly in children with a history of infantile spasms (IS). The goal of this study was to prospectively examine the effect on cognitive outcome of a neuroprotective agent used as adjunctive therapy during treatment of the spasms. Methods: In a randomized controlled trial, patients received a standardized therapy plus flunarizine or placebo. The standardized treatment consisted of vigabatrin as first-line therapy. Nonresponders were switched to intramuscular synthetic adrenocorticotropic hormone (sACTH depot) after 2 weeks and, if necessary, to topiramate after two additional weeks. The Vineland Adaptive Behavior Scale (VABS) and Bayley Scales of Infant Development (BSID) were used as outcome measures 24 months after the intervention. Key Findings: Sixty-eight of 101 children diagnosed over 3 years in seven centers in Canada received either adjunctive flunarizine or placebo. Sixty-five of the 68 children (96%) became spasm-free within 8 weeks and no late relapse occurred. Bayley and Vineland results were available at baseline and at 24 months in 45 children. There was no significant difference in the BSID developmental quotient between the flunarizine- and placebo-treated children at baseline (44.3 +/- 35.5 vs. 30.9 +/- 29.8; p = 0.18) or 24 months later (56.9 +/- 33.3 vs. 46 +/- 34.2; p = 0.29). However, the 10 flunarizine-treated children with no identified etiology had a better outcome than the eight controls at 24 months on both the Vineland Scale (84.1 +/- 11.3 vs. 72.3 +/- 9.8; p = 0.03) and the Bayley Scale (87.6 +/- 14.7 vs. 69.9 +/- 25.3; p = 0.07). Significance: Our study failed to demonstrate a protective effect of flunarizine on cognitive outcome in a cohort of children with IS. An analysis of subgroups suggested that flunarizine may further improve cognitive outcome in children with no identified etiology.

• 出版日期2012-9