A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria

作者：Feng, Xiao; Zhang, Tao; Liu, Jin-Ting; Miao, Jun-Ying^*; Zhao, Bao-Xiang^*

来源：Chemical communications, 2016, 52(15): 3131-3134.

DOI：10.1039/c5cc09267a

• OFF-ON RESPONSE
• LIVING CELLS
• BIOIMAGING APPLICATIONS
• BIOLOGICAL-SYSTEMS
• DESIGN STRATEGIES
• RATIONAL DESIGN
• REDOX CYCLE
• SE-BODIPY
• H2S
• CATIONS

We have developed a new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism. The probe showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation. The probe targeted mitochondria with high selectivity and sensitivity toward H2S.

• 出版日期2016
• 单位山东大学