Antioxidant Activity and Mechanism of Action of Some Synthesised Phenolic Acid Amides of Aromatic Amines

作者：Marinova Emma^*; Georgiev Lubomir; Totseva Iskra; Seizova Katya; Milkova Tsenka

来源：Czech Journal of Food Sciences, 2013, 31(1): 5-13.

• cinnamic acid derivatives
• phenylpropenoyl amides of aromatic amines
• triacylglycerols of sunflower oil

MARINOVA E., GEORGIEV L., TOTSEVA I., SEIZOVA K., MILKOVA T. (2013): Antioxidant activity and mechanism of action of some synthesised phenolic acid amides of aromatic amines. Czech J. Food Sci., 31: 5-13. The antioxidative activities and mechanism of action were studied of eight synthesised cinnamoyl- and hydroxycinnamoyl amides of biogenic amines (caffeoyldopamine, cinnamoyldopamine, p-coumaroyldopamine, feruloyldopamine, sinapoyldopamine, caffeoylphenylethylamine, caffeoyltyramine, and caffeoyltryptamine) in a wide concentration range (2.5-20 x 10(-4)M) during autoxidation of triacylglycerols of sunflower oil. It was established that all amides exhibited excellent antioxidant activity, higher than or comparable with that of caffeic acid. The best activity was shown by caffeoyldopamine followed by cinnamoyldopamine and caffeoyltyramine. The analysis of the kinetic data obtained showed that the presence of hydroxyl groups in the amino part (derivatives of dopamine and tyramine) led to direct oxidation of the molecules during the process and stabilisation of the resulting radicals. In contrast, the amides without hydroxyl groups in the amino part participated in the side reaction with peroxides and the resulting radicals took part in one side reaction of the chain propagation as did caffeic acid.

• 出版日期2013
• 单位西南大学