A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging

作者：Yang, Hong; Ding, Liang; An, Lu; Xiang, Zheyuan; Chen, Min; Zhou, Jing; Li, Fuyou^*; Wu, Dongmei; Yang, Shiping

来源：Biomaterials, 2012, 33(33): 8591-8599.

DOI：10.1016/j.biomaterials.2012.07.067

• d-f heteronuclear complex
• Ir-Gd complex
• Phosphorescence imaging
• Magnetic resonance imaging

A d-f heteronuclear complex (Ir-Gd) by coupling an iridium(III) complex to a macrocycle-based gadolinium complex has been developed as as a dual-mode bioimaging probe for luminescence imaging and magnetic resonance imaging (MRI). The cyclometalated iridium complex showed an intense visible metal-to-ligand charge transfer (MLCT) absorption and strong yellow phosphorescent luminescence. It has specificity of staining in murine mitochondria confirmed by confocal laser scanning microscopy. The macrocycle-based gadolinium complex provides the longitudinal relaxivity of 3.36 mM(-1)s(-1) on a 3 T system, which has been applied to MRI for liver in mice. Furthermore, the biodistribution of Ir-Gd has been investigated using inductively coupled plasma atomic emission spectroscopy (ICP-AES) analyses. Such platform should be extended to further applications in the identification and diagnosis of liver diseases.

• 出版日期2012-11
• 单位复旦大学; 上海师范大学; 华东师范大学