Dosimetric evaluation of nanotargeted Re-188-liposome with the MIRDOSE3 and OLINDA/EXM programs

作者：Chang Chih Hsien; Chang Ya Jen; Lee Te Wei; Ting Gann; Chang Kwo Ping^*

来源：Annals of Nuclear Medicine, 2012, 26(5): 419-425.

DOI：10.1007/s12149-012-0593-4

• Dosimetry
• Internal radiotherapy
• MIRDOSE3
• OLINDA/EXM
• Rhenium-188

The OLINDA/EXM computer code was created as a replacement for the widely used MIRDOSE3 code for radiation dosimetry in nuclear medicine. A dosimetric analysis with these codes was performed to evaluate nanoliposomes as carriers of radionuclides (Re-188-liposomes) in colon carcinoma-bearing mice. %26lt;br%26gt;Pharmacokinetic data for Re-188-N, N-bis (2-mercaptoethyl)-N%26apos;,N%26apos;-diethylethylenediamine (Re-188-BMEDA) and Re-188-liposome were obtained for estimation of absorbed doses in normal organs. Radiation dose estimates for normal tissues were calculated using the MIRDOSE3 and OLINDA/EXM programs for a colon carcinoma solid tumor mouse model. %26lt;br%26gt;Mean absorbed doses derived from(188)Re-BMEDA and Re-188-liposome in normal tissues were generally similar as calculated by MIRDOSE3 and OLINDA/EXM programs. One notable exception to this was red marrow, wherein MIRDOSE3 resulted in higher absorbed doses than OLINDA/EXM (1.53- and 1.60-fold for Re-188-BMEDA and Re-188-liposome, respectively). %26lt;br%26gt;MIRDOSE3 and OLINDA have very similar residence times and organ doses. Bone marrow doses were estimated by designating cortical bone rather than bone marrow as a source organ. The bone marrow doses calculated by MIRDOSE3 are higher than those by OLINDA. If the bone marrow is designated as a source organ, the doses estimated by MIRDOSE3 and OLINDA programs will be very similar.

• 出版日期2012-6