Disruption of parental-specific expression of imprinted genes in uniparental fetuses

作者：Ogawa Hidehiko; Wu Qiong; Komiyama Junichi; Obata Yayoi; Kono Tomohiro^*

来源：FEBS Letters, 2006, 580(22): 5377-5384.

DOI：10.1016/j.febslet.2006.08.087

• androgenote
• parthenogenote
• imprinted genes
• mouse

In mammals, imprinted genes show parental origin-dependent expression based on epigenetic modifications called genomic imprinting (GI), which are established independently during spermatogenesis or oogenesis. Due to GI, uniparental fetuses never develop to term. To determine whether such expression of imprinted genes is maintained in uniparental mouse fetuses, we analyzed the expression of 20 paternally and 11 maternally expressed genes in androgenetic and parthenogenetic fetuses. Four genes of each type were expressed in both groups of fetuses. Furthermore, quantitative analysis showed that expression levels deviated from the presumed levels for some imprinted genes. These results suggest that mechanisms acting in trans between paternal and maternal alleles are involved in the appropriate expression of some imprinted genes.

• 出版日期2006-10-2