Postrehabilitation Functional Improvements in Patients With Inflammatory Myopathies: The Results of a Randomized Controlled Trial

作者：Tiffreau Vincent^*; Rannou Francois; Kopciuch Francois; Hachulla Eric; Mouthon Luc; Thoumie Philippe; Sibilia Jean; Drumez Elodie; Thevenon Andre

来源：Archives of Physical Medicine and Rehabilitation, 2017, 98(2): 227-234.

DOI：10.1016/j.apmr.2016.09.125

• Myositis
• Quality of life
• Rehabilitation

Objective: To evaluate the medium-term functional effect and the effect on quality of life of a standardized rehabilitation program in patients with inflammatory myopathies (IMs).
Design: A multicenter, randomized controlled trial.
Setting: Four university hospitals.
Participants: Patients (N=21) with polymyositis.
Interventions: The intervention group participated in a 4-week standardized, hospital-based rehabilitation program followed by a personalized, self-managed, home-based rehabilitation program. The control group received physiotherapy on an outpatient basis. Study participants were evaluated at inclusion, at the end of the rehabilitation program (lmo), and then at 6 and 12 months.
Main Outcome Measures: The primary efficacy criterion was the Health Assessment Questionnaire Disability Index (HAQ-DI), and the secondary criteria were quality of life (according to the Medical Outcomes Study 36-Item Short-Form Health Survey [SF-36] questionnaire), muscle performance (isokinetic strength, Motor Function Measure, and Kendall Manual Muscle Test), gait, pain, fatigue, and biomarkers of tolerance and disease activity.
Results: At 12 months, the mean +/- SD HAQ-DI was significantly lower in the intervention group than in the control group (.64 +/-.53 vs 1.36 +/- 1.02; P=.026). The intervention group also had better scores than the control group for some quality-of-life dimensions (SF-36 General Health: 53.44 +/- 8.73 vs 36.57 +/- 22.10, respectively; P=.038; SF-36 Role Physical: 63.89 +/- 43.50 vs 17.86 +/- 37.40, respectively; P=.023) and pain levels (5.0 +/- 10.61 vs 33.38 +/- 35.68, respectively; P=.04) at 12 months. The program was well tolerated by all the participants.
Conclusions: In patients with IMs, the combination of a 4-week standardized rehabilitation program and a personalized, home-based, self managed rehabilitation program was well tolerated and had a positive medium-term functional effect.

• 出版日期2017-2