Mouse ooplasm confers context-specific reprogramming capacity

作者：Chan Michelle M; Smith Zachary D; Egli Dieter; Regev Aviv; Meissner Alexander^*

来源：Nature Genetics, 2012, 44(9): 978-980.

DOI：10.1038/ng.2382

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

• 出版日期2012-9