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摘要
Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small regulatory RNAs that are approximately 22 nucleotides long, which direct the post-transcriptional regulation of diverse target genes and control cell states. Transforming growth factor (TGF)-beta family is a multifunctional cytokine family, which plays many regulatory roles in the development and pathogenesis of diverse diseases, including fibrotic disease, cardiovascular disease and cancer. Previous studies have shown that the TGF-beta pathway includes the miRNA pathway as an important component of its downstream signaling cascades. Multiple studies of epithelial-mesenchymal transition (EMT)-related miRNAs have highlighted that miRNAs constitute the intrinsic bistable molecular switches of cell states by forming double negative feedback loops with EMT-inducing transcription factors. This may be important for understanding the reversibility of EMT at the single-cell level, the presence of distinct EMT transition states and the intra- and inter-tumor heterogeneity of cancer cell phenotypes. In the present review, I summarize the connection between TGF-beta signaling and the miRNA pathway, placing particular emphasis on the regulation of miRNA expression by TGF-beta signaling, the modulation of TGF-beta signaling by miRNAs, the miRNA-mediated modulation of EMT and endothelial-mesenchymal transition as well as the crosstalk between miRNA and TGF-beta pathways in the tumor microenvironment.
- 出版日期2018-7
- 单位MIT
