Microwave-assisted synthesis of substituted pyrazoles and pyrazolo [3,4-d]thiopyrimidines

作者：Heravi MM^*; Nami N; Seifi N; Oskooie HA; Hekmatshoar R

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2006, 181(3): 591-599.

DOI：10.1080/10426500500269646

• ethylcyanoacetate
• malononitrile
• pyrazolo[3,4-d]thiopyrimidine
• triethyl orthoacetate
• triethyl orthoformate

Ethyl(ethoxymethylene)cyanoacetate and ethoxymethylene malononitrile were synthesized from the reaction of malononitrile or ethylcyanoacetate with triethyl ortho-formate or orthoacetate in N, N-dimethylacetamide under microwave irradiation. In a similar manner, substituted pyrazoles were synthesized from the reaction of ethyl (ethoxymethylene)cyanoacetate and ethoxymethylene malononitrile with phenylhydrazine. These pyrazoles were converted to pyrazolo[3,4-d]thiopyrimidines upon treatment with arylisothiocyanate and thiourea under microwave irradiation.

• 出版日期2006-3