An efficient synthesis of styrenyl enamides from 4-aryl-2-oxazolidinones in the presence of strong base

作者：Zou, Kaihe; Ye, Jinxing^*; Wu, Xin-Yan

来源：Tetrahedron Letters, 2015, 56(41): 5517-5520.

DOI：10.1016/j.tetlet.2015.08.026

• Enamides
• Lithium diisopropylamine
• Oxazolidinones
• Thioxooxazolidines
• Thioxothiazolidines

Efficient synthesis of styrenyl enamides can be achieved from the corresponding 4-aryl-2-oxazolidinones, 2-thioxooxazolidines, and 2-thioxothiazolidines in the presence of the strong base lithium diisopropylamine. The reaction proceeded efficiently to achieve the enamides in good to excellent yields (up to 92%). This reaction provides an easy, rapid, and good-yielding method for the synthesis of styrenyl enamides.

• 出版日期2015-10-7
• 单位华东理工大学