Antiviral Potential of Exogenous Human Omega Interferon to Inhibit Pandemic 2009A (H1N1) Influenza Virus

作者：Xu, Chun'e; Song, Xiaohong; Fu, Ling; Dong, Dayong; Wu, Shipo; Li, Guanlin; Yi, Shaoqiong; Yu, Ting; Yu, Rui; Hou, Lihua; Chen, Wei^*

来源：Viral Immunology, 2011, 24(5): 369-374.

DOI：10.1089/vim.2011.0003

• ALPHA-INTERFERON
• PATHOGENESIS
• FERRETS
• MICE

The pandemic 2009 H1N1 influenza virus broke out in North America and spread rapidly throughout the world. The type I interferon (IFN) response represents one of the first lines of defense against influenza virus infections. In this study, the protective potential of human exogenous IFN-omega against pandemic 2009A (H1N1) influenza virus was assessed both in vitro and in guinea pigs. The viral loads of pandemic 2009A (H1N1) influenza virus strains A/California/04/2009 and A/Beijing/501/2009 were reduced by up to 5000-fold in Caco-2 cells by the addition of human IFN-omega. With daily intranasal treatment with human IFN-omega the viral load of pandemic 2009A (H1N1) influenza virus strain A/California/04/2009 decreased by 1000-fold in lung tissues of guinea pigs. These results provide strong support for the application of human IFN-omega pretreatment to human influenza control.

• 出版日期2011-10