科研之友
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摘要
Background The aim of this research is to show the morphometric effect of nandrolone that is used as doping in sport on femur of rats in puberty period.
Material/Methods: A total of 60 Sprague-Dawley rats (30 days old) were divided into three equal groups. The control group (male n = 10, female n = 10) was nourished for 4 weeks without any substance being administered. For the peanut oil group (male n = 10, female n = 10), peanut oil was used as diluent of nandrolone decanoate (500 mcl). It was administered for 5 days via intraperitoneal injection, with a pause of 2 days and the same application was done for 4 weeks.. Nandrolone decanoate was applied for 5 days to the Nandrolone group (male n = 10, female n = 10) in 10 mg/kg dose by being diluted in 500 mcl peanut oil via intraperitoneal injection and the same was applied for 4 weeks having taken a 2-day long pause. Rats were euthanatized at the end of fourth week. Back extremity bones of materials were revealed by being dissected and put to maceration operation.
Results: Morphometric measures were taken by determining the anatomic reference points (length, corpus, cortex-cortical bone thickness-substantiate compact, medullar wide-cavity medullar) that would be measured of femur bones that are on right side. It was determined that nandrolone caused shortening in femur length (p<0.05) in male and female rats when compared to peanut oil and control groups.
Conclusions: Nandrolone may delay the bone formation in the puberty period.
- 出版日期2010-12-31
